Is it possible to use a VB.NET program as the front-end interface and have it call C programs from, say, a menu or button click?
It all depends on what you mean by "call C programs." If you mean start standalone .EXE programs written in C: absolutely. Look at the Process class on how to start processes. If it means calling C functions in a .DLL, that works as well, but is more work. You'll need to read up on InterOp and how to declare the C functions in such a way that you can call them from .NET.
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