The easy way is to go to the Mono project Web site, and check its MySQL data provider. You can use it just like the SQL data provider that comes with .NET. You have many other providers there also at http://www.go-mono.org/ado-net.html. An interesting article explaining how to use MySQL from .NET can be found at http://www.mysql.com/articles/dotnet/.
This was first published in December 2003